Studied Ingredients for Better Bowel Regularity, Reduction in Bloating & Inflammation

We take great pride in offering ingredients that have undergone rigorous testing and boast an impressive body of study evidence showcasing their efficacy. We believe in transparency and quality - here's a snapshot of the studies about our key ingredients. 

Bowel Function - Adult 

Andresen. Efficacy of freeze-dried Lactobacilli in functional diarrhoea: a pilot study. Deutsche Medizinische  Wochenschrift. 2012: 137:1792-1796 

Tarrerias. The Effect of Inactivated Lactobacillus LB Fermented Culture Medium on Symptom Severity:  Observational Investigation in 297 Patients with Diarrhea-Predominant Irritable Bowel Syndrome. Digestive  Diseases. 2011. 29:588-591 

Dr. Yap Soo Kor Jason. Lacteol Fort Treatment Reduces Antibiotic Associated Diarrhea. The Singapore Family  Physician, Sept 2010; 36(4):46-49 

Xiao. Multicenter, Randomized, Controlled Trial of Heat-Killed Lactobacillus acidophilus LB in Patients with Chronic  Diarrhea. Advances in Therapy. 2003, 20(5):253-260 

Halpern. Treatment of Irritable Bowel Syndrome with Lacteol Fort: A Randomized, Double-Blind, Cross-Over Trial.  The American Journal of Gastroenterology. 1996: 91(8):1579-1585 

Bodilis. A Reference Product-Controlled and Placebo-Controlled Study of Lacteol Fort in Acute Diarrhea in Adults.  Médecine actuelle. 1983; 10:232-235 

Bowel Function – Children 

Elfrargy. Oral Probiotics Reduce Incidence of Necrotizing Enterocolitis and Sepsis in Neonates with Hypoxic Ischemic  Encephalopathy. Journal of American Science. 2014; 10(10) 

Lievin-Le Moal. An Experimental Study and a Randomized, Double-Blind, Placebo-Controlled Clinical Trial to  Evaluate the Antisecretory Activity of Lactobacillus acidophilus Strain LB Against Nonrotavirus Diarrhea. Pediatrics. October 2007; 120(4):795-803 

Salazar-Lindo. Effectiveness and Safety of Lactobacillus LB in the Treatment of Mild Acute Diarrhea in Children.  Journal of Pediatric Gastroenterology and Nutrition. 2007, 44(5):571-576 

Simakachorn. Clinical Evaluation of the Addition of Lyophilized, Heat-killed Lactobacillus acidophilus LB to Oral  Rehydration Therapy in the Treatment of Acute Diarrhea in Children. Journal of Pediatric Gastroenterology and  Nutrition. 2000, 30(1):68-72 

Boulloche. Management of Acute Diarrhea in Infants and Toddlers. Controlled study of antidiarrheal efficacy of  killed L.acidophilis (LB strain) versus placebo and a reference agent (loperamide). Pediatric Annals. 1994;  41(7):457-463 

Upper GI Function 

Canducci. A lyophilized and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori  eradication rates. Alimentary Pharmacology & Therapeutics. 2000; 14:1625-1629

Gut Inflammatory Response 

Warda. Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter  induced Colitis. Frontiers in Microbiology. January 2020. Volume 11. Article 69 

Hegazy. Effect of Probiotics on Pro-inflammatory Cytokines and NF-κB Activation in Ulcerative Colitis. World  Journal of Gastroenterology. 2010 September 7; 16(33):4145-4151 

Brush Boarder & Tight Junction Effects 

Montalto. Lactobacillus acidophilus Protects Tight Junctions from Aspirin Damage in HT-29 Cells. Digestion  2004;69:225-229 

Lievin-Le Moal. Lactobacillus acidophilus (strain LB) from the resident adult human gastrointestinal microflora  exerts activity against brush border damage promoted by a diarrhoeagenic Escherichia coli in human enterocyte like cells. Gut 2002; 50:803-811 

Lievin-Le Moal. Impairment of swimming motility by Antidiarrheic Lactobacillus acidophilus Strain LB retards  internalization of Salmonella enterica Serovar Typhimurium within human enterocyte-like cells. Antimicrobial  Agents and Chemotherapy. Oct 2011; 55(10):4810-4820 

Control of Undesirable Bacteria 

Coconnier. A Lactobacillus acidophilus Strain of Human Gastrointestinal Microbiota Origin Elicits Killing of  Enterovirulent Salmonella enterica Serovar Typhimurium by Triggering Lethal Bacterial Membrane Damage.  Applied and Environmental Microbiology. October 2005, p.6115-6120 

Coconnier. Antagonistic Activity of Lactobacillus acidophilus LB against Intracellular Salmonella enterica Serovar  Typhimurium Infecting Human Enterocyte-like Caco-2/TC-7 Cells. Applied and Environmental Microbiology. March  2000, p.1152-1157 

Coconnier. Antagonistic Activity against Helicobacter Infection In Vitro and In Vivo by the Human Lactobacillus  acidophilus Strain LB. Applied and Environmental Microbiology. November 1998, p.4573-4580 

Coconnier. Anitbacterial Effect of the Adhering Human Lactobacillus acidophilus Strain LB. Antimicrobial Agents  and Chemotherapy. May 1997. 41(5). 1046-1052.  

Moyen. Effect of Erythromycin and an Extract of Heat-Killed Lactobacillus acidophilus on Intestinal Colonization  and Translocation of Campylobacter jujuni in the Axenic Mouse. Annales de L’Institut Pasteur/Microbiologie.  1986, 137:199-207 

Fourniat. Effect of Killed Lactobacillus acidophilus Administration on the Survival of Suckling Mice Infected with  Enterotoxigenic Escherichia coli. Annals of Veterinary Research. 1986, 17(4), 401-407 

Adherence Mechanism of LB

Chauviere. Adhesion of Human Lactobacillus acidophilus strain LB to human enterocyte-like Caco-2 cells. Journal of  General Microbiology. 1992; 138:1689-1696.  

Prevents Adhesion of Undesirable Bacteria 

Coconnier. Adhering Heat-killed Lactobacillus acidophilus, Strain LB, Inhibits the Process of Pathogenicity of  Diarrhoegenic Bacteria in Cultured Human Intestinal Cells. J. Diarrhoeal Dis Res. 1993 Dec; 11(4):235-242. 

Coconnier. Inhibition of adhesion of enteroinvasive pathogens to human intestinal Caco-2 cells by Lactobacillus  acidophilus strain LB decreases bacterial invasion. FEMS Microbiology Letters. 1993; 110:299-306. 

Chauviere. Competitive exclusion of diarrheagenic Escherichia coli (ETEC) from human enterocyte-like Caco-2 cells  by heat-killed Lactobacillus. FEMS Microbiology Letters. 1992; 91:213-218. 

Fourniat. Heat-killed Lactobacillus acidophilus inhibits adhesion of Escherichia coli B41 to HeLa cells. Annals of  Veterinary Research. 1992; 23:361-370. 

Immunostimulating Effects 

German. Immunostimulating Activity of Lacteol Fort. Pharmaceutical Studies Centre, Immunology & Microbiology  Departments, Chatenay-Malbry, France. June 1981 (Internal Report) 

Meta-Analysis/Summaries 

Liévin-Le Moal. A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated Lactobacillus LB.  Therapeutic Advances in Gastroenterology. 2016; 9(1):57-75 

Liévin-Le Moal. Anti-infective Activities of Lactobacillus Strains in the Human Intestinal Microbiotia: from Probiotics  to Gastrointestinal Anti-infectious Biotherapeutic Agents. Clinical Microbiology Reviews. April 2014, 27(2): 167- 199 

Animal Treatment 

Abu-Braka. Filed studies on some probiotics to minimize hazard effects of prevailing heavy metals contamination  for improving immunity and growth performance of Oreochromis niloticus Electronic Physician. April 2017. 9(4).  4138-4144 (Tilapia) 

Khalil. Effect of Lactobacillus acidophilus on the Growth and Immune Response in Cultured Oreochromis niloticus.  Global Journal of Fisheries and Aquaculture Researches; 2014: 1(2):57-69 (Tilapia) 

Attia. Capability of different non-nutritive feed additives on improving productive and physiological traits of broiler  chicks fed diets with or without aflatoxin during the first 3 weeks of life. Journal of Animal Physiology and Animal  Nutrition. 2012 (Broilers) 

Abd-Elrahman. Colibacillosis in Newly Born Buffalo Calves and Role of Lacteol Fort in Preventing Recurrence of Calf  Diarrhea. Life Science Journal. 2011;8(4) (Calves) 

Other Studies

El-Ghazely. Effect of Probiotic Administration in the Therapy of Pediatric Thermal Burn. Annals of Burns and Fire  Disasters. December 2016. Vol XXIX – n.4