Studied Ingredients for Better Bowel Regularity, Reduction in Bloating & Inflammation
We take great pride in offering ingredients that have undergone rigorous testing and boast an impressive body of study evidence showcasing their efficacy. We believe in transparency and quality - here's a snapshot of the studies about our key ingredients.
Bowel Function - Adult
Andresen. Efficacy of freeze-dried Lactobacilli in functional diarrhoea: a pilot study. Deutsche Medizinische Wochenschrift. 2012: 137:1792-1796
Tarrerias. The Effect of Inactivated Lactobacillus LB Fermented Culture Medium on Symptom Severity: Observational Investigation in 297 Patients with Diarrhea-Predominant Irritable Bowel Syndrome. Digestive Diseases. 2011. 29:588-591
Dr. Yap Soo Kor Jason. Lacteol Fort Treatment Reduces Antibiotic Associated Diarrhea. The Singapore Family Physician, Sept 2010; 36(4):46-49
Xiao. Multicenter, Randomized, Controlled Trial of Heat-Killed Lactobacillus acidophilus LB in Patients with Chronic Diarrhea. Advances in Therapy. 2003, 20(5):253-260
Halpern. Treatment of Irritable Bowel Syndrome with Lacteol Fort: A Randomized, Double-Blind, Cross-Over Trial. The American Journal of Gastroenterology. 1996: 91(8):1579-1585
Bodilis. A Reference Product-Controlled and Placebo-Controlled Study of Lacteol Fort in Acute Diarrhea in Adults. Médecine actuelle. 1983; 10:232-235
Bowel Function – Children
Elfrargy. Oral Probiotics Reduce Incidence of Necrotizing Enterocolitis and Sepsis in Neonates with Hypoxic Ischemic Encephalopathy. Journal of American Science. 2014; 10(10)
Lievin-Le Moal. An Experimental Study and a Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Antisecretory Activity of Lactobacillus acidophilus Strain LB Against Nonrotavirus Diarrhea. Pediatrics. October 2007; 120(4):795-803
Salazar-Lindo. Effectiveness and Safety of Lactobacillus LB in the Treatment of Mild Acute Diarrhea in Children. Journal of Pediatric Gastroenterology and Nutrition. 2007, 44(5):571-576
Simakachorn. Clinical Evaluation of the Addition of Lyophilized, Heat-killed Lactobacillus acidophilus LB to Oral Rehydration Therapy in the Treatment of Acute Diarrhea in Children. Journal of Pediatric Gastroenterology and Nutrition. 2000, 30(1):68-72
Boulloche. Management of Acute Diarrhea in Infants and Toddlers. Controlled study of antidiarrheal efficacy of killed L.acidophilis (LB strain) versus placebo and a reference agent (loperamide). Pediatric Annals. 1994; 41(7):457-463
Upper GI Function
Canducci. A lyophilized and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori eradication rates. Alimentary Pharmacology & Therapeutics. 2000; 14:1625-1629
Gut Inflammatory Response
Warda. Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter induced Colitis. Frontiers in Microbiology. January 2020. Volume 11. Article 69
Hegazy. Effect of Probiotics on Pro-inflammatory Cytokines and NF-κB Activation in Ulcerative Colitis. World Journal of Gastroenterology. 2010 September 7; 16(33):4145-4151
Brush Boarder & Tight Junction Effects
Montalto. Lactobacillus acidophilus Protects Tight Junctions from Aspirin Damage in HT-29 Cells. Digestion 2004;69:225-229
Lievin-Le Moal. Lactobacillus acidophilus (strain LB) from the resident adult human gastrointestinal microflora exerts activity against brush border damage promoted by a diarrhoeagenic Escherichia coli in human enterocyte like cells. Gut 2002; 50:803-811
Lievin-Le Moal. Impairment of swimming motility by Antidiarrheic Lactobacillus acidophilus Strain LB retards internalization of Salmonella enterica Serovar Typhimurium within human enterocyte-like cells. Antimicrobial Agents and Chemotherapy. Oct 2011; 55(10):4810-4820
Control of Undesirable Bacteria
Coconnier. A Lactobacillus acidophilus Strain of Human Gastrointestinal Microbiota Origin Elicits Killing of Enterovirulent Salmonella enterica Serovar Typhimurium by Triggering Lethal Bacterial Membrane Damage. Applied and Environmental Microbiology. October 2005, p.6115-6120
Coconnier. Antagonistic Activity of Lactobacillus acidophilus LB against Intracellular Salmonella enterica Serovar Typhimurium Infecting Human Enterocyte-like Caco-2/TC-7 Cells. Applied and Environmental Microbiology. March 2000, p.1152-1157
Coconnier. Antagonistic Activity against Helicobacter Infection In Vitro and In Vivo by the Human Lactobacillus acidophilus Strain LB. Applied and Environmental Microbiology. November 1998, p.4573-4580
Coconnier. Anitbacterial Effect of the Adhering Human Lactobacillus acidophilus Strain LB. Antimicrobial Agents and Chemotherapy. May 1997. 41(5). 1046-1052.
Moyen. Effect of Erythromycin and an Extract of Heat-Killed Lactobacillus acidophilus on Intestinal Colonization and Translocation of Campylobacter jujuni in the Axenic Mouse. Annales de L’Institut Pasteur/Microbiologie. 1986, 137:199-207
Fourniat. Effect of Killed Lactobacillus acidophilus Administration on the Survival of Suckling Mice Infected with Enterotoxigenic Escherichia coli. Annals of Veterinary Research. 1986, 17(4), 401-407
Adherence Mechanism of LB
Chauviere. Adhesion of Human Lactobacillus acidophilus strain LB to human enterocyte-like Caco-2 cells. Journal of General Microbiology. 1992; 138:1689-1696.
Prevents Adhesion of Undesirable Bacteria
Coconnier. Adhering Heat-killed Lactobacillus acidophilus, Strain LB, Inhibits the Process of Pathogenicity of Diarrhoegenic Bacteria in Cultured Human Intestinal Cells. J. Diarrhoeal Dis Res. 1993 Dec; 11(4):235-242.
Coconnier. Inhibition of adhesion of enteroinvasive pathogens to human intestinal Caco-2 cells by Lactobacillus acidophilus strain LB decreases bacterial invasion. FEMS Microbiology Letters. 1993; 110:299-306.
Chauviere. Competitive exclusion of diarrheagenic Escherichia coli (ETEC) from human enterocyte-like Caco-2 cells by heat-killed Lactobacillus. FEMS Microbiology Letters. 1992; 91:213-218.
Fourniat. Heat-killed Lactobacillus acidophilus inhibits adhesion of Escherichia coli B41 to HeLa cells. Annals of Veterinary Research. 1992; 23:361-370.
Immunostimulating Effects
German. Immunostimulating Activity of Lacteol Fort. Pharmaceutical Studies Centre, Immunology & Microbiology Departments, Chatenay-Malbry, France. June 1981 (Internal Report)
Meta-Analysis/Summaries
Liévin-Le Moal. A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated Lactobacillus LB. Therapeutic Advances in Gastroenterology. 2016; 9(1):57-75
Liévin-Le Moal. Anti-infective Activities of Lactobacillus Strains in the Human Intestinal Microbiotia: from Probiotics to Gastrointestinal Anti-infectious Biotherapeutic Agents. Clinical Microbiology Reviews. April 2014, 27(2): 167- 199
Animal Treatment
Abu-Braka. Filed studies on some probiotics to minimize hazard effects of prevailing heavy metals contamination for improving immunity and growth performance of Oreochromis niloticus Electronic Physician. April 2017. 9(4). 4138-4144 (Tilapia)
Khalil. Effect of Lactobacillus acidophilus on the Growth and Immune Response in Cultured Oreochromis niloticus. Global Journal of Fisheries and Aquaculture Researches; 2014: 1(2):57-69 (Tilapia)
Attia. Capability of different non-nutritive feed additives on improving productive and physiological traits of broiler chicks fed diets with or without aflatoxin during the first 3 weeks of life. Journal of Animal Physiology and Animal Nutrition. 2012 (Broilers)
Abd-Elrahman. Colibacillosis in Newly Born Buffalo Calves and Role of Lacteol Fort in Preventing Recurrence of Calf Diarrhea. Life Science Journal. 2011;8(4) (Calves)
Other Studies
El-Ghazely. Effect of Probiotic Administration in the Therapy of Pediatric Thermal Burn. Annals of Burns and Fire Disasters. December 2016. Vol XXIX – n.4
